Glioma pathogenesis-related protein 1-like, SCP domain (IPR034121)

Short name: SCP_GLIPR-1-like

Overlapping homologous superfamilies

Domain relationships

  • CAP domain (IPR014044)
    • Glioma pathogenesis-related protein 1-like, SCP domain (IPR034121)


This SCP-like extracellular protein domain is found in the glioma pathogenesis-related protein (GLIPR) subfamily, which consists of GLIPR1, GLIPR1-like 1 (GLIPR1L1), and GLIPR1-like 2 (GLIPR1L2). GLIPR1 and GLIPR1L2 are expressed in several tissues, whereas GLIPR1L1 is expressed predominantly in the testis and is involved in the binding of sperm to the oocyte complex [PMID: 20219979, PMID: 22552861].

The SCP domain is also known as CAP domain [PMID: 18824526]. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a C-terminal cysteine rich domain, and allergen 5 from vespid venom. It has been proposed that SCP domains may function as endopeptidases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.