Protein S100-A6 (IPR034118)

Short name: S-100A6

Overlapping homologous superfamilies

Family relationships



S100A6 is a member of the S100 domain family within the EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A6 group belongs, contains only S-100 EF-hand domains, other EF-hands have been modeled separately [PMID: 11390274]. S100 proteins exhibit unique patterns of tissue- and cell type-specific expression and have been implicated in the Ca2+-dependent regulation of diverse physiological processes, including cell cycle regulation, differentiation, growth, and metabolic control [PMID: 9519412, PMID: 10395934, PMID: 10191501, PMID: 16683912].

S100A6 is normally expressed in the G1 phase of the cell cycle in neuronal cells. The function of S100A6 remains unclear, but evidence suggests that it is involved in cell cycle regulation and exocytosis. S100A6 may also be involved in tumorigenesis; the protein is overexpressed in several tumours. Ca2+ binding to S100A6 leads to a conformational change in the protein, which exposes a hydrophobic surface for interaction with target proteins. Several such proteins have been identified: glyceraldehyde-3-phosphate dehydrogenase, annexins 2, 6 and 11 and Calcyclin-Binding Protein (CacyBP) [PMID: 11833360, PMID: 15336958].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.