Domain

AGE domain (IPR034116)

Short name: AGE_dom

Domain relationships

None.

Description

N-acyl-D-glucosamine 2-epimerase (also known as AGE) is responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. The catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is structurally and mechanistically distinct from the other four types of epimerases. The AGE domain monomer is composed of an alpha(6)/alpha(6)-barrel, the structure of which is also found in glucoamylase and cellulase. The active form is a homodimer. The alignment also contains subtype III mannose 6-phosphate isomerases [PMID: 11706991].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD