Lsm16, N-terminal (IPR034107)

Short name: Lsm16_N

Overlapping homologous superfamilies


Domain relationships


This entry represents the N-terminal of the Lsm16 protein.

Lsm16 (also known as enhancer of decapping-3 or EDC3) has been shown to be associated with an mRNA-decapping complex Dcp1-Dcp2, required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end. EDC3 is believed to be a scaffold for decapping complex formation [PMID: 16580207, PMID: 22085934, PMID: 21957006]. It belongs to a family of Sm-like proteins that associate with RNA to form complexes involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold, containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet, that associates with other Sm proteins to form hexameric and heptameric ring structures [PMID: 10801455]. Lsm16 has, in addition to its N-terminal Sm-like domain, a C-terminal Yjef_N-type Rossmann fold domain of unknown function [PMID: 15225602].

GO terms

Biological Process

GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA

Molecular Function

GO:0003729 mRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.