Sm-like protein Lsm1 (IPR034104)

Short name: Lsm1

Overlapping homologous superfamilies

Domain relationships


This entry represents Sm-like protein Lsm1. It can be found in the cytoplasmic Lsm1-7 complex, which associates with deadenylated mRNA and promotes decapping in the 5'-3' mRNA decay pathway [PMID: 22615807, PMID: 10801455].

The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [PMID: 24513854].

GO terms

Biological Process

GO:0000956 nuclear-transcribed mRNA catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.