Sm-like protein Lsm8 (IPR034103)

Short name: Lsm8

Overlapping homologous superfamilies

Domain relationships



This entry represents Sm-like protein Lsm8. It is found in the nuclear Lsm2-8 complex, which associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). The Lsm2-8 complex binds and stabilizes the 3'-terminal poly(U) tract of U6 snRNA and facilitates the assembly of U4-U6 di-snRNP and U4-U6-U5 tri-snRNP [PMID: 22615807, PMID: 15916535, PMID: 24240276].

The Sm and the Lsm proteins, characterised by the Sm-domain, have RNA-related functions. The Sm heptamer ring associates with four (U1, U2, U4, U5) snRNPs, while Lsm2-8 heptamer is part of the U6 snRNP. Another Lsm heptameric complex, Lsm1-7, which differs from Lsm2-8 by one Lsm protein, functions in mRNA decapping, a crucial step in the mRNA degradation pathway [PMID: 24513854].

GO terms

Biological Process

GO:0000398 mRNA splicing, via spliceosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0005688 U6 snRNP

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.