Small nuclear ribonucleoprotein F (IPR034100)
Short name: Sm_F
Overlapping homologous superfamilies
- LSM domain superfamily (IPR010920)
- Sm-like protein Lsm6/SmF (IPR016487)
- Small nuclear ribonucleoprotein F (IPR034100)
This entry represents small nuclear ribonucleoprotein F (SmF).
The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons [PMID: 10369684, PMID: 11259661, PMID: 11226169]. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet [PMID: 10025403].
Sm subunit F is capable of forming both homo- and hetero-heptamer ring structures. To form the hetero-heptamer, Sm subunit F initially binds subunits E and G to form a trimer which then assembles onto snRNA along with the D3/B and D1/D2 heterodimers [PMID: 18984161, PMID: 23333303].
- cd01722 (Sm_F)