PARN, R3H domain (IPR034042)

Short name: PARN_R3H

Overlapping homologous superfamilies

Domain relationships

  • R3H domain (IPR001374)
    • PARN, R3H domain (IPR034042)


This is the R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family which, in Xenopus deadenylates a specific class of maternal mRNAs that results in their translational repression [PMID: 17624302, PMID: 16281054, PMID: 11424938]. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA [PMID: 9787637].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.