Tumor necrosis factor receptor 21, death domain (IPR034037)

Short name: TNFRSF21_death

Overlapping homologous superfamilies

Domain relationships

  • Death domain (IPR000488)
    • Tumor necrosis factor receptor 21, death domain (IPR034037)


This death domain (DD) is found in tumor necrosis factor receptor superfamily member 21 (TNFRSF21), also called death receptor-6, or DR6. DR6 is an orphan receptor that is expressed ubiquitously, but shows high expression in lymphoid organs, heart, brain and pancreas [PMID: 19760075]. Results from DR6(-/-) mice indicate that DR6 plays an important regulatory role for the generation of adaptive immunity. It may also be involved in tumor cell survival and immune evasion. In neuronal cells, it binds beta-amyloid precursor protein (APP) and activates caspase-dependent cell death [PMID: 19225519].

In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [PMID: 7482697, PMID: 17201679].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.