Serralysin-like metallopeptidase domain (IPR034033)

Short name: Serralysin-like

Overlapping homologous superfamilies

Domain relationships


This entry includes zinc-dependent metalloprotease domains from the serralysin and related proteins such as PbrA from Pseudomonas [PMID: 16385113]. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in Gram-negative bacteria, that does not require N-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain C-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides [PMID: 15322010, PMID: 8253063, PMID: 8089845].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.