Domain

Attractin-like, C-type lectin-like domain (IPR034011)

Short name: Attractin-like_CTLD

Overlapping homologous superfamilies

Domain relationships

Description

This C-type lectin-like domain (CTLD) is found in human and mouse attractin (AtrN) and attractin-like protein (ALP). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. Mouse AtrN (the product of the mahogany gene) has been shown to bind Agouti protein and to function in agouti-induced pigmentation and obesity [PMID: 11137996]. Mutations in AtrN have also been shown to cause spongiform encephalopathy and hypomyelination in rats and hamsters [PMID: 12654511, PMID: 11209055, PMID: 11773967]. The cytoplasmic region of mouse ALP has been shown to bind to melanocortin receptor (MCR4) [PMID: 14531729]. Signaling through MCR4 plays a role in appetite suppression. Attractin may have therapeutic potential in the treatment of obesity [PMID: 14656215]. Human attractin (hAtrN) has been shown to be expressed on activated T cells and released extracellularly. The circulating serum attractin induces the spreading of monocytes that become the focus of the clustering of non-proliferating T cells [PMID: 11168005, PMID: 10849745, PMID: 9736737].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD