Family

Peptidyl-dipeptidase DCP (IPR034005)

Short name: M3A_DCP

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry includes the following members of peptidase subfamily M3A: peptidyl dipeptidase DCP (EC 3.4.15.5; MEROPS identifier M03.005; also known as dipeptidyl carboxypeptidase) and oligopeptidase A (OpdA; EC 3.4.24.70; MEROPS identifier M03.004). DCP releases dipeptides from the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from E. coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A) [PMID: 19558329, PMID: 15876371]. Oligopeptidase A (OpdA) may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala [PMID: 7674945].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008233 peptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD