Pathways & interactions
ATP-binding cassette transporter, PDR-like subfamily G, domain 2 (IPR034003)
Short name: ABCG_PDR_2
Overlapping homologous superfamilies
- ABC transporter-like (IPR003439)
- ATP-binding cassette transporter, PDR-like subfamily G, domain 2 (IPR034003)
This entry represents the second domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette (ABC) transporters.
Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes [PMID: 12430018]. This PDR subfamily represents domain II of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules [PMID: 10529352]. The nucleotide binding domain shows the highest similarity between all members of the family [PMID: 11551790]. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins [PMID: 10529352], [PMID: 11435397].
- cd03232 (ABCG_PDR_domain2)