CEL-1-like C-type lectin-like domain (IPR033988)

Short name: CEL1-like_CTLD

Overlapping homologous superfamilies

Domain relationships


This entry represents the C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata, and Echinoidin from Anthocidaris crassispina amongst others. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins [PMID: 9433125]. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc) [PMID: 11752793, PMID: 15319425]. CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc [PMID: 15713882]. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc [PMID: 3571253]. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD [PMID: 1915838]. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.