Electron transfer flavoprotein, alpha subunit, N-terminal (IPR033947)

Short name: ETF_alpha_N

Overlapping homologous superfamilies

Domain relationships


The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase [PMID: 8962055]. ETF is an heterodimer that consists of an alpha and a beta subunit which binds one molecule of FAD per dimer. A similar system also exists in some bacteria. The homologous pair of proteins (FixA/FixB) are essential for nitrogen fixation [PMID: 8525056]. The alpha subunit of ETF is structurally related to the bacterial nitrogen fixation protein fixB which could play a role in a redox process and feed electrons to ferredoxin [PMID: 2326318].

This entry refers to an N-terminal domain found predominantly in the alpha subunit of ETF.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.