Branched-chain aminotransferase (IPR033939)

Short name: BCAT_family

Overlapping homologous superfamilies

Family relationships


Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leucine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two forms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme [PMID: 12686109]. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism [PMID: 11642362]. Members of this entry are widely distributed in all three forms of life.

GO terms

Biological Process

GO:0009081 branched-chain amino acid metabolic process

Molecular Function

GO:0004084 branched-chain-amino-acid transaminase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.