FAM43A/B, phosphotyrosine-binding domain (IPR033930)

Short name: FAM43A/B_PTB

Overlapping homologous superfamilies

Domain relationships

  • PTB/PI domain (IPR006020)
    • FAM43A/B, phosphotyrosine-binding domain (IPR033930)


Proteins encoding phosphotyrosine binding (PTB) domains function as adaptors or scaffolds to organise the signaling complexes involved in wide-ranging physiological processes including neural development, immunity, tissue homeostasis and cell growth. Due to structural differences, PTB domains are divided into three groups represented by phosphotyrosine-dependent IRS-like, phosphotyrosine-dependent Shc-like, and phosphotyrosine-independent Dab-like PTBs. The last two PTBs have been named as phosphotyrosine interaction domain (PID or PI domain). PID domain has an average length of about 160 amino acids [PMID: 15567406].

The function of family with sequence similarity 43, member A (FAM43A) is currently unknown. Human FAM43A is located on chromosome 3 at location 3q29. It encodes a 3182 base pair mRNA which possesses one Pleckstrin homology-like domain. The mRNA translates into LOC131583, a hydrophilic protein that is predicted to localize in the nucleus. The FAM43A gene is conserved through a broad range of vertebrates. It is highly conserved from chimpanzees to zebrafish.

This entry refers to the PTB domain found in FAM43A/B.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.