Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain (IPR033928)

Short name: EPS8_PTB

Overlapping homologous superfamilies

Domain relationships


Epidermal growth factor receptor kinase substrate (EPS8) is a regulator of Rac signaling [PMID: 12127568,PMID: 14565974,PMID: 11099046]. It consists of a phosphotyrosine-binding (PTB) and an SH3 domain.

PTB domains have a common PH-like fold and are found in various eukaryotic signaling molecules [PMID: 10610414]. This domain was initially shown to binds peptides with a NPXY motif with differing requirements for phosphorylation of the tyrosine, although more recent studies have found that some types of PTB domains can bind to peptides lack tyrosine residues altogether [PMID: 11911882]. In contrast to SH2 domains, which recognize phosphotyrosine and adjacent carboxy-terminal residues, PTB-domain binding specificity is conferred by residues amino-terminal to the phosphotyrosine [PMID: 11994738]. PTB domains are classified into three groups: phosphotyrosine-dependent Shc-like, phosphotyrosine-dependent IRS-like, and phosphotyrosine-independent Dab-like PTB domains [PMID: 15567406].

The entry refers to the PTB domain found in EPS8, part of the Dab-like subgroup.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.