DPS-like protein, ferritin-like diiron-binding domain (IPR033921)

Short name: DPSL_diiron-bd_dom

Overlapping homologous superfamilies

Domain relationships


Dps-like proteins are members of the broad superfamily of ferritin-like diiron-carboxylate proteins, which are non-haem iron storage proteins [PMID: 12730463]. The Dps-like protein from Sulfolobus solfataricus is structurally related to a class of DNA-binding protein from starved cells (Dps). It has been experimentally characterised and shown to self-assemble into a hollow dodecameric protein cage having tetrahedral symmetry, which uses H2O2 to oxidize Fe(II) to Fe(III), storing the oxide as a mineral core on the interior surface of the protein cage. Members of the Dps-like family may therefore be involved in the mitigation of oxidative damage [PMID: 16024730].

This entry represents the ferritin-like diiron-binding domain of Dps-like proteins. Many of the conserved residues of a diiron centre are present in this domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008199 ferric iron binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.