Lipase, N-terminal (IPR033906)

Short name: Lipase_N

Overlapping homologous superfamilies

Domain relationships


This entry includes the catalytic, N-terminal domain of pancreatic lipase-like enzymes.

Triglyceride lipases (EC: are lipolytic enzymes that hydrolyse ester linkages of triglycerides [PMID: 3147715]. Lipases are widely distributed in animals, plants and prokaryotes. At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC:, which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL) [PMID: 2917565]. The most conserved region in all these proteins is centred around a serine residue which has been shown [PMID: 2304545] to participate, with an histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase (EC: (LCAT) [PMID: 3458198], which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol.

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.