UDP-GlcNAc-dolichyl-phosphate GlcNAc phosphotransferase (IPR033895)

Short name: GPT

Overlapping homologous superfamilies


Family relationships


UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol [PMID: 1668306]. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is essential for eukaryotic N-glycosylation [PMID: 7734839]. GPT activity has been identified in all eukaryotic cells examined to date. A series of six conserved motifs designated A through F, ranging in length from 5 to 13 amino acid residues, has been identified in this family. They have been determined to be important for stable expression, substrate binding, or catalytic activities [PMID: 9592129].

GO terms

Biological Process

GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0006487 protein N-linked glycosylation

Molecular Function

GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.