Domain

GDP-mannose 3,5-epimerase (IPR033890)

Short name: GDP-Man_epi

Overlapping homologous superfamilies

Domain relationships

None.

Description

This subgroup of NDP-sugar epimerase/dehydratases are extended short-chain dehydrogenase/reductases (SDRs); they have the characteristic active site tetrad, and an NAD-binding motif: TGXXGXX[AG], which is a close match to the canonical NAD-binding motif. Members include Arabidopsis thaliana GDP-mannose-3',5'-epimerase which catalyzes the epimerization of GDP-alpha-D-mannose to form GDP-beta-L-galactose [PMID: 16366586]. It also catalyses an epimerization reaction that releases GDP-L-gulose, an intermediate that could be dedicated for the de novo biosynthesis of vitamin C in plants [PMID: 12954627].

Extended SDRs are distinct from classical SDRs. In addition to the Rossmann fold (alpha/beta folding pattern with a central beta-sheet) core region typical of all SDRs, extended SDRs have a less conserved C-terminal extension of approximately 100 amino acids [PMID: 7742302, PMID: 19011750, PMID: 12604210, PMID: 12604213].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0047918 GDP-mannose 3,5-epimerase activity
GO:0051287 NAD binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD