Dihydroorotate dehydrogenase, class 1A (IPR033886)

Short name: DHOD_1A

Overlapping homologous superfamilies

Family relationships


Dihydroorotate dehydrogenase (DHOD) catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires FMN as co-factor. DHOD is divided into class 1 and class 2 based on their amino acid sequences and cellular location. Members of class 1 are cytosolic enzymes and multimers, while class 2 enzymes are membrane associated and monomeric. The class 1 enzymes can be further divided into subtypes 1A and 1B which are homodimers and heterotetrameric proteins, respectively [PMID: 11520193, PMID: 15196933, PMID: 12732650].

This entry represents class 1A.

GO terms

Biological Process

GO:0006221 pyrimidine nucleotide biosynthetic process

Molecular Function

GO:0004152 dihydroorotate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.