Alkane/xylene monooxygenase (IPR033885)

Short name: AlkB/XylM

Overlapping homologous superfamilies


Family relationships


Alkane hydroxylase AlkB catalyzes the terminal hydroxylation of alkanes and the omega-hydroxylation of fatty acids in the presence of a NADH-rubredoxin reductase and rubredoxin [PMID: 921275]. It is an integral membrane di-iron enzyme that shares a requirement for iron and oxygen for activity in a manner similar to that of the non-heme integral membrane desaturases [PMID: 12804773]. Alcanivorax borkumensis has two alkane hydroxylases, AlkB1 and AlkB2, with AlkB1 being responsible for the degradation of short-chain n-alkanes [PMID: 14871210, PMID: 14871203, PMID: 19953301].

Also included in this family is xylene monooxygenase, a related enzyme with broad specificity that oxidizes toluene and xylenes to (methyl)benzyl alcohols [PMID: 1999388, PMID: 7947684].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.