Flagellum site-determining protein FlhG (IPR033875)

Short name: FlhG

Overlapping homologous superfamilies

Domain relationships



FlhG (also annotated FleN/YlxH) is an ATPase that regulates location and number of bacterial flagella [PMID: 10629180, PMID: 23600726, PMID: 25733861]. FlhG acts antagonistically with FlhF/FleQ to regulate the number of polar flagella, with FlhF promoting flagellar assembly and FlhG inhibiting it. FlhG interacts with FlhF and influences its GTPase activity [PMID: 24167275, PMID: 26411371].

FlhG and FlhF are responsible for generating the single polar flagellum of Pseudomonas sps and Vibrio cholerae. In these bacteria, FlhG represses the activity or expression of a master transcriptional regulator [PMID: 16159765], FleQ in the case of Pseudomonas [PMID: 11673434, PMID: 26841764]. Campylobacter jejuni FlhG likely influences a flagellar biosynthetic step to control flagellar number, rather than suppressing activators of flagellar gene transcription as in Vibrio and Pseudomonas species [PMID: 26411371]. On the peritrichous bacterium Bacillus subtilis, FlhF and FlhG function together to spatially organize flagella in a defined grid-like pattern around the cellular midpoint, but not at polar regions [PMID: 23190039].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.