Ribosome assembly factor Mrt4 (IPR033867)

Short name: Mrt4

Overlapping homologous superfamilies


Family relationships


Mrt4 is a ribosomal stalk protein P0 (or Rpp0) paralogue involved in ribosome biogenesis and mRNA turnover [PMID: 11583614, PMID: 10471698]. P0 is cytoplasmic and is present in cytoplasmic pre-60S particles and mature 60S subunits. Mrt4, however, is nuclear and has been identified in pre-60S ribosome complexes but not in mature 60S subunits, suggesting that it binds ribosomes at an early stage of assembly in the nucleolus and during assembly it is exchanged for P0. The dual-specificity phosphatase Yvh1 is required for Mrt4 displacement from the pre-60S subunit [PMID: 19797078]. P0 is required for the release of Mrt4 and exchanges with this factor at the cytoplasm [PMID: 19789271].

GO terms

Biological Process

GO:0000027 ribosomal large subunit assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.