Brcc36 isopeptidase (IPR033860)

Short name: MPN_BRCC36

Overlapping homologous superfamilies


Family relationships



BRCC36 (BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex subunit 3; BRCC3; BRISC complex subunit BRCC36; BRCC36 isopeptidase complex; Lys-63-specific deubiquitinase BRCC36; MEROPS identifier M67.004) and BRCC36-like proteins are JAMM/MPN+ deubiquitinases (DUBs), possibly with Zn2+-dependent ubiquitin isopeptidase activity. BRCC36 specifically cleaves Lys 63-linked polyubiquitin chains [PMID: 20656690].

BRCC36 is part of the BRCA1/BRCA2/BARD1-containing nuclear complex that displays an E3 ubiquitin ligase activity [PMID: 14636569]. It is targeted to DNA damage foci after irradiation; RAP80 recruits the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA double strand breaks (DSBs) for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs [PMID: 19202061, PMID: 17525341]. BRCC36 exists in at least two distinct complexes, the RAP80 complex (also called the BRCA1-A complex) and the BRCC36 isopeptidase complex (BRISC) [PMID: 20656690, PMID: 21282113, PMID: 26195665].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0070536 protein K63-linked deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.