Carboxypeptidase O (IPR033850)

Short name: Carboxypeptidase_O

Overlapping homologous superfamilies


Domain relationships


Peptidase M14 carboxypeptidase (CP) O (CPO, also known as metallocarboxypeptidase C; MEROPS identifier M14.021; EC 3.4.17.) belongs to the carboxypeptidase A/B subfamily of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity [PMID: 11766880]. CPO releases acidic C-terminal residues. It is active at neutral pH and is membrane attached via a glycosylphosphatidinylinositol membrane anchor at the C terminus [PMID: 21921028].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004181 metallocarboxypeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.