Asparaginase-like 1, metazoa (IPR033844)

Short name: ASRGL1_meta

Overlapping homologous superfamilies

Family relationships


Human asparaginase-like protein 1 (ASRGL1) [PMID: 19839645] and similar proteins constitute a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1, and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha and beta subunits. The threonine becomes the N-terminal residue of the beta subunit and is the catalytic residue [PMID: 23601642,PMID: 22861376]. Because of this autolytic cleavage, the ASRGL1 precursor is considered a peptidase (MEROPS identifier T02.002). ASRGL1, or asparaginase-like 1, has been cloned from mammalian testis cDNA libraries. It has been identified as a sperm antigen that may induce the production of autoantibodies following obstruction of the male reproductive tract, e.g. vasectomy [PMID: 11984834].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004067 asparaginase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.