Ubiquitin-specific peptidase 38 (IPR033840)

Short name: USP38

Overlapping homologous superfamilies


Domain relationships


Ubiquitin carboxyl-terminal hydrolases (UCH) (EC: [PMID: 1647207] are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. The deubiquitinsing proteases can be split into 2 size ranges, 20-30 kDa (IPR001578) and 100-200 kDa [PMID: 7845226]: the second class consist of large proteins (800 to 2000 residues) that belong to the peptidase family C19, and this group is currently represented by yeast UBP1 [PMID: 2050695].

This entry includes the peptidase domain of ubiquitin-specific peptidase 38 (USP38; MEROPS identifier C19.056), which belongs to the second group of deubiquitinsing proteases. It has specificity for 'Lys-63'-linked ubiquitin chains [PMID: 22689415].

GO terms

Biological Process

GO:0006511 ubiquitin-dependent protein catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.