Maspin (IPR033836)

Short name: SERPINB5

Overlapping homologous superfamilies

Domain relationships


Maspin (mammary serine proteinase inhibitor; Serpin B5; MEROPS identifier I04.980) is a non-inhibitory member of the serpin superfamily (clade B) [PMID: 11116082, PMID: 24172014], with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer [PMID: 15501821,PMID: 15353283,PMID: 8290962].

In general, SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms [PMID: 24172014]. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones [PMID: 3502621].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.