Domain

Alpha2-antiplasmin (IPR033833)

Short name: Alpha2AP

Overlapping homologous superfamilies

Domain relationships

Description

Alpha2-antiplasmin (alpha2AP; plasmin inhibitor; MEROPS identifier I04.023) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-antiplasmin forms an inactive 1:1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin during blood clotting by activated coagulation factor XIII, and as a consequence fibrin becomes more resistant to fibrinolysis. Therefore alpha2AP is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin [PMID: 15320781,PMID: 11460480]. Alpha2-antiplasmin corresponds to clade F2 of the serpin superfamily (MEROPS family I4) [PMID: 11116082, PMID: 24172014].

GO terms

Biological Process

GO:0051918 negative regulation of fibrinolysis

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD