Pigment epithelium derived factor (IPR033832)

Short name: PEDF

Overlapping homologous superfamilies

Domain relationships

  • Serpin domain (IPR023796)
    • Pigment epithelium derived factor (IPR033832)


Pigment epithelium-derived factor (PEDF) is a non-inhibitory member of the Serpin superfamily (MEROPS family I4; MEROPS identifier I04.979). It exhibits neurotrophic, neuroprotective and antiangiogenic properties and is widely expressed in the developing and adult nervous systems [PMID: 12894238,PMID: 12530532,PMID: 12114112]. This subgroup corresponds to clade F1 of the serpin superfamily [PMID: 11116082, PMID: 24172014].

GO terms

Biological Process

GO:0016525 negative regulation of angiogenesis
GO:0050769 positive regulation of neurogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.