D-aminopeptidase DppA (IPR033824)

Short name: DppA

Overlapping homologous superfamilies

Family relationships


This entry contains the D-aminopeptidase dipeptide-binding protein (dppA; DAP dppA; MEROPS identifier M55.001). Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed [PMID: 11069674]. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif [PMID: 11473256]. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates [PMID: 11069674]. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel [PMID: 1766370].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008237 metallopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.