Domain

Nuclear receptor-interacting protein, peptidase domain (IPR033821)

Short name: NRIP_C

Overlapping homologous superfamilies

Domain relationships

Description

Proteins with this domain have been described as probable nuclear receptor interacting proteins. This C-terminal domain is homologous to the retroviral aspartyl protease domain. The domain is structurally related to one lobe of the pepsin molecule. The conserved active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate peptidases is classified by MEROPS as the peptidase family A28, with the identifier A28.002 [PMID: 7674916,PMID: 1455179,PMID: 17199106].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004190 aspartic-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD