Pre-mRNA-splicing regulator WTAP (IPR033757)

Short name: WTAP

Overlapping homologous superfamilies


Family relationships


Pre-mRNA-splicing regulator WTAP (Wilms' tumor 1-associating protein) is a regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) formation, which acts as an epitranscriptomic marker [PMID: 24407421, PMID: 24316715]. It plays a role in the efficiency of mRNA splicing and processing, and mRNA stability [PMID: 17088532]. In Drosophila, the homologous protein pfemale-lethal(2)D has been implicated in alternative splicing regulation of genes involved in sexual determination [PMID: 12444081] and is required for eye development [PMID: 24690230]. FKBP12-interacting protein of 37 kDa (AtFIP37, At3g54170), the homologue from Arabidopsis, may also have a role in splicing events [PMID: 15047892]. AtFIP37 interacts with mRNA adenosine methylase (MTA, encoded by At4g10760) in vitro and in vivo [PMID: 18505803].

GO terms

Biological Process

GO:0080009 mRNA methylation
GO:0000381 regulation of alternative mRNA splicing, via spliceosome

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.