Family

Glycine cleavage system H-protein/Simiate (IPR033753)

Short name: GCV_H/Fam206

Overlapping homologous superfamilies

Family relationships

Description

This is a family of glycine cleavage H-proteins, part of the glycine cleavage system (GCS) found in bacteria, archaea, and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine [PMID: 11286922]. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue [PMID: 8197146].

This enty includes simiate proteins. Simiate (also known as FAM206A) functions in transcription regulation [PMID: 24349419]. Furthermore, it associates with both G- and F-Actin and affects actin polymerization and actin turnover, influencing filopodia dynamics and arborization of neurons [PMID: 24782708].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam