Prokaryote proline-tRNA ligase core domain (IPR033730)

Short name: ProRS_core_prok

Overlapping homologous superfamilies

Domain relationships


Prolyl-tRNA synthetase (ProRS) is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. ProRS is a homodimer. There are two structurally distinct classes of aminoacyl-tRNA synthetases; ProRS has been assigned to class II based upon its structure and the presence of three characteristic sequence motifs in the core domain [PMID: 7552701, PMID: 10447505, PMID: 11732603, PMID: 14665676]. The core domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate.

This entry contains the core domain of ProRS from prokaryotes and from the mitochondria of eukaryotes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.