PET prickle (IPR033723)

Short name: PET_prickle

Overlapping homologous superfamilies


Domain relationships


Prickle has been implicated in regulation of cell movement in the planar cell polarity (PCP) pathway [PMID: 12874125], which requires the conserved Frizzled/Dishevelled (Dsh). Prickle interacts with Dishevelled [PMID: 15937478], thereby modulating the activity of Frizzled/Dishevelled and the PCP signaling. Two forms of prickle have been identified, namely prickle 1 and prickle 2. These are differentially expressed; prickle 1 is found in fetal heart and hematological malignancies, while prickle 2 is expressed in fetal brain, adult cartilage, pancreatic islet, and some types of tumorous cells [PMID: 12525887].

Prickle contains an N-terminal PET domain and three C-terminal LIM domains. This entry represents the PET domain of prickle. The PET domain is a protein-protein interaction domain, usually found in conjunction with the LIM domain, which is also involved in protein-protein interactions. The PET containing proteins serve as adaptors or scaffolds to support the assembly of multimeric protein complexes.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.