Serine/threonine-protein kinase Plk4 (IPR033700)

Short name: Plk4

Overlapping homologous superfamilies


Family relationships



Polo-like kinases (Plks) belong to the serine/threonine kinase subfamily, and are characterized by the presence of the signature motif called Polo-box domain. Plks are key regulators of cell cycle and cell division in eukaryotes [PMID: 15173822, PMID: 26786872]. Unicellular organisms contain one Plk whereas higher eukaryotes have as many as four Plks: Plk1, Plk2, Plk3 and Plk4.

Plk4 (also called Sak) is the most structurally divergent member of the Plks. It plays a pivotal role in centriole duplication [PMID: 21968988, PMID: 16326102, PMID: 16244668, PMID: 17681131, PMID: 17383880] and is required for centriolar satellite function and ciliogenesis [PMID: 26755742]. Substrates identified for Plk4 include Cdc25C and Chk2 [PMID: 18239451, PMID: 19164942].

GO terms

Biological Process

GO:0007099 centriole replication
GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

GO:0005814 centriole

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.