Ribonuclease T2, eukaryotic (IPR033697)

Short name: Ribonuclease_T2_eukaryotic

Overlapping homologous superfamilies

Family relationships


Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases) [PMID: 12109772, PMID: 11582795, PMID: 10446375, PMID: 12731868, PMID: 11158587]. Plant T2 RNases are expressed during leaf senescence in order to scavenge phosphate from ribonucleotides. They are also expressed in response to wounding or pathogen invasion. S-RNases are thought to prevent self-fertilization by acting as selective cytotoxins of "self" pollen. Generally, RNases have two distinct binding sites: the primary site (B1 site) and the subsite (B2 site), for nucleotides located at the 5'- and 3'- terminal ends of the sissile bond, respectively.

This entry includes the eukaryotic RNase T2 family members.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.