Active Site

Pyroglutamyl peptidase I, Cys active site (IPR033694)

Short name: PGPEP1_Cys_AS


Pyroglutamyl peptidase I (EC: (also known as PGP-1, pyrrolidone-carboxylate peptidase, PYRase) is the enzyme that selectively removes pyroglutamate (pGlu) from the N terminus of proteins and peptides. PGP-I is widely found in bacteria, plants and animals [PMID: 10196127].

In bacteria and archebacteria PYRase (gene pcp) is a protein of 22-24 kDa. It is a cysteine protease with a Cys-His-Glu catalytic triad [PMID: 10368293, PMID: 10196127]. This entry represents the cysteine active site.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns