Phosphatidylserine decarboxylase, eukaryotic type 1 (IPR033661)

Short name: PSD_type1_euk

Overlapping homologous superfamilies


Family relationships


Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [PMID: 8407984]. Phosphatidylserine decarboxylases EC: is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids [PMID: 7890740].

Phosphatidylserine decarboxylases (PSDs) have been classified in two types. Type I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic cleavage sites where proenzymes are split into alpha and beta subunits [PMID: 19165886].

A non-mitochondrial type I phosphatidylserine decarboxylase has been identified in Plasmodium falciparum [PMID: 14651609].

This entry represents the eukaryotic type 1 subfamily.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004609 phosphatidylserine decarboxylase activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.