RelA, TGS domain (IPR033655)

Short name: TGS_RelA

Overlapping homologous superfamilies

Domain relationships

  • TGS (IPR004095)
    • RelA, TGS domain (IPR033655)


The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after the Threonyl-tRNA Synthetase, GTPase, and SpoT proteins where it occurs. The function of the TGS domain is unknown [PMID: 21858139].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.