Mitochondrial ribosomal protein L46 NUDIX (IPR033650)

Short name: MRP_L46_NUDIX

Overlapping homologous superfamilies

Domain relationships



Mitochondrial ribosomal protein L46 (MRP L46) is a component of the large subunit (39S) of the mammalian mitochondrial ribosome and a member of the Nudix hydrolase superfamily. MRPs are thought to be involved in the maintenance of the mitochondrial DNA. In general, members of the Nudix superfamily require a divalent cation, such as Mg2+ or Mn2+, for activity and contain the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), which functions as a metal binding and catalytic site. MRP L46 appears to contain a modified NUDIX motif [PMID: 16378245, PMID: 15581572, PMID: 8810257, PMID: 16359314].

This entry represents the MRP L46 NUDIX motif-containing domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.