Homeobox protein NKX-2.5 (IPR033629)

Short name: NKX-2.5

Overlapping homologous superfamilies


Family relationships



Homeobox genes play fundamental roles in specifying cell fate and positional identity in embryos. Homeobox gene Csx/Nkx2.5, one of the vertebrate homologues of Drosophila tinman, is expressed in the precardiac mesoderm and in the myocardium of the embryonic and adult heart [PMID: 7690144, PMID: 7904557] and is one of the master regulators of cardiac development, homeostasis and disease [PMID: 19546853, PMID: 10021345]. Csx associates with the transcription factor GATA4 and this interaction may regulate a subset of cardiac muscle-specific genes [PMID: 9584153]. Nkx2-5 regulates the gene encoding the Kcnh2 channel [PMID: 26897459].

GO terms

Biological Process

GO:0060048 cardiac muscle contraction
GO:0007507 heart development
GO:1903779 regulation of cardiac conduction
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.