Serine/threonine-protein kinase MARK3 (IPR033628)

Short name: MARK3

Overlapping homologous superfamilies


Family relationships



MAP/microtubule affinity-regulating kinases (MARKs) are serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) causing their detachment from the microtubules, thereby increasing microtubule dynamics [PMID: 9108484, PMID: 10542369]. They phosphorylate a variety of substrates, including MAPs, Dishevelled, histone deacetylase [PMID: 19559622], Doublecortin [PMID: 14741102] and PSD-95 [PMID: 22807451]. As their homologue in C. elegans par-1, they are involved in the establishment of cell polarity [PMID: 7758115, PMID: 20023164, PMID: 19559622, PMID: 17981131]. They are also involved in regulating body glucose homeostasis and energy metabolism [PMID: 17372192, PMID: 22992738,PMID: 17721078]. They share a similar structure, consisting of an N-terminal kinase domain, a ubiquitin-associated domain, and a kinase-associated domain [PMID: 23471664].

There are four members of the mammalian MARK family, MARK1-4. This entry represents MARK3. Mice null for MARK3/Par-1a/C-TAK1 exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal insulin sensitivity [PMID: 20733003]. Both MARK3 and MARK4 associate with early tau phosphorylation in Alzheimer's disease [PMID: 24533944].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.