Interleukin-1 receptor-associated kinase-like 2 (IPR033611)

Short name: IRAK2

Overlapping homologous superfamilies

Family relationships



Interleukin-1 receptor-associated kinase-like 2 (IRAK2) is a critical mediator of TLR/IL1-R signalling [PMID: 9374458, PMID: 20485341]. It is required for production of pro-inflammatory cytokines [PMID: 18438411, PMID: 23918981].

All IRAKs are multidomain proteins, consisting of a conserved N-terminal death domain (DD) and a central kinase domain (KD). The DD is a protein interaction motif implicated in binding to the adaptor protein MyD88 [PMID: 9374458]. IRAK2 lacks an active kinase domain, as a critical residue in the kinase domain has changed [PMID: 12620219].

GO terms

Biological Process

GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0006954 inflammatory response
GO:0070498 interleukin-1-mediated signaling pathway
GO:0001959 regulation of cytokine-mediated signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.