Interleukin-1 receptor-associated kinase 3 (IPR033610)

Short name: IRAK3

Overlapping homologous superfamilies

Family relationships



Interleukin-1 receptor-associated kinase 3 (IRAK3/IRAK-M) is a negative regulator of MyD88-dependent Toll-like receptor (TLR) signalling [PMID: 12150927]. It is expressed in monocytes/macrophages and lung epithelial cells. Structurally, IRAK3 consists of a kinase domain (KD) flanked by an N-terminal death domain (DD) involved in binding to other IRAK family members and an unstructured C-terminal domain. The kinase domain lacks the critical active site aspartate residue and IRAK-M appears devoid of kinase activity [PMID: 10383454, PMID: 20599782]. IRAK-M may inhibit inflammation through several mechanisms, including stabilization of MKP-1 [PMID: 17379480] and down-regulation of the non-canonical NFkB pathway [PMID: 19809574]. It can also induce NFkB activation to produce inhibitory molecules as a negative feedback for the pathway [PMID: 23376919].

GO terms

Biological Process

GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0045824 negative regulation of innate immune response
GO:0034122 negative regulation of toll-like receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.