E3 ubiquitin-protein ligase RNF152 (IPR033609)

Short name: RNF152

Overlapping homologous superfamilies

Family relationships



RING finger protein 152 (RNF152) has E3 ligase activity involved in lysosome-related apoptosis [PMID: 21203937]. It is a negative regulator of the mTORC1 pathway by targeting RagA for K63-linked ubiquitination [PMID: 25936802].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:1904262 negative regulation of TORC1 signaling
GO:0010508 positive regulation of autophagy
GO:0000209 protein polyubiquitination

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

GO:0005764 lysosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.